Restoration of hand function in a rat model of repair of brachial plexus
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Christopher
- Posts: 845
- Joined: Wed Jun 18, 2003 10:09 pm
- Injury Description, Date, extent, surgical intervention etc: Date of Injury: 12/15/02
Level of Injury:
-dominant side C5, C6, & C7 avulsed. C8 & T1 stretched & crushed
BPI Related Surgeries:
-2 Intercostal nerves grafted to Biceps muscle,
-Free-Gracilis muscle transfer to Biceps Region innervated with 2 Intercostal nerves grafts.
-2 Sural nerves harvested from both Calves for nerve grafting.
-Partial Ulnar nerve grafted to Long Triceps.
-Uninjured C7 Hemi-Contralateral cross-over to Deltoid muscle.
-Wrist flexor tendon transfer to middle, ring, & pinky finger extensors.
Surgical medical facility:
Brachial Plexus Clinic at The Mayo Clinic, Rochester MN
(all surgeries successful)
"Do what you can, with what you have, where you are."
~Theodore Roosevelt - Location: Los Angeles, California USA
Restoration of hand function in a rat model of repair of brachial plexus
I'm going to try and find out if there is an easier way to help donate to this research.
I believe it is the cure in waiting for BPI!!!
Christopher
http://www.ncbi.nlm.nih.gov/pubmed/1928 ... d_RVDocSum
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Brain. 2009 Mar 13.
Restoration of hand function in a rat model of repair of brachial plexus injury.
Ibrahim AG, Kirkwood PA, Raisman G, Li Y.
1 Department of Brain Repair and Rehabilitation, Spinal Repair Unit, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
The incurability of spinal cord injury and subcortical strokes is due to the inability of nerve fibres to regenerate. One of the clearest clinical situations where failure of regeneration leads to a permanent functional deficit is avulsion of the brachial plexus. In current practice, surgical re-implantation of avulsed spinal roots provides a degree of motor recovery, but the patients neither recover sensation nor the use of the hand. In the present rat study, we show that transplantation of cultured adult olfactory ensheathing cells restores the sensory input needed for a complex, goal-directed fore-paw function and re-establishes synaptic transmission to the spinal grey matter and cuneate nucleus by providing a bridge for regeneration of severed dorsal root fibres into the spinal cord. Success in a first application of human olfactory ensheathing cells in clinical brachial plexus injury would open the way to the wider field of brain and spinal cord injuries.
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want to help fund this research?
http://www.ion.ucl.ac.uk/research/hbir/ ... r_unit.htm
We are actively seeking further support to maintain the programme.
Enquiries or donations should be sent to the Fund Development Officer, BNRT, Spinal Repair Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG.
I believe it is the cure in waiting for BPI!!!
Christopher
http://www.ncbi.nlm.nih.gov/pubmed/1928 ... d_RVDocSum
=========================================================
Brain. 2009 Mar 13.
Restoration of hand function in a rat model of repair of brachial plexus injury.
Ibrahim AG, Kirkwood PA, Raisman G, Li Y.
1 Department of Brain Repair and Rehabilitation, Spinal Repair Unit, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
The incurability of spinal cord injury and subcortical strokes is due to the inability of nerve fibres to regenerate. One of the clearest clinical situations where failure of regeneration leads to a permanent functional deficit is avulsion of the brachial plexus. In current practice, surgical re-implantation of avulsed spinal roots provides a degree of motor recovery, but the patients neither recover sensation nor the use of the hand. In the present rat study, we show that transplantation of cultured adult olfactory ensheathing cells restores the sensory input needed for a complex, goal-directed fore-paw function and re-establishes synaptic transmission to the spinal grey matter and cuneate nucleus by providing a bridge for regeneration of severed dorsal root fibres into the spinal cord. Success in a first application of human olfactory ensheathing cells in clinical brachial plexus injury would open the way to the wider field of brain and spinal cord injuries.
--------------------------------------------
want to help fund this research?
http://www.ion.ucl.ac.uk/research/hbir/ ... r_unit.htm
We are actively seeking further support to maintain the programme.
Enquiries or donations should be sent to the Fund Development Officer, BNRT, Spinal Repair Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG.
Re: Restoration of hand function in a rat model of repair of brachial plexus
Thanks for posting this Christopher...We all need to get behind those doing research. We can donate our own money and also try to get charitable organizations to give as well as push for government funding. Its seems like the science is at a place were a cure is possible...
We need to act.
We need to act.
