United Brachial Plexus Network, Inc.

Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury.

Discussion
In this study, we explored the potential of transplanted human ESC-derived neural progenitors to assist in restoring a sensory conduit from the periphery into the spinal cord in a dorsal root avulsion injury model and to investigate their ability to generate new neurons which may serve as replacements for avulsion induced cell loss in the spinal cord. Our findings support the conclusion that such transplants contribute to partial functional recovery by supporting sensory axon growth into the host spinal cord.